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Once released, VIP relaxes smooth muscle, increases intestinal blood flow, and stimulates fluid and electrolyte secretion

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It can also cause bloating and either constipation or diahorrea, or sometimes both

This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]